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Smallpox vaccine - Discovery

 
     
 

 

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Who Invented The Smallpox Vaccine?

The much dreaded, but much needed poke in most developing countries. The drops that are administered even before the child realizes what is happening. Aren’t these the pictures that come to mind when one thinks of vaccinations? There's more to vaccination than just these. There is vaccine against polio and vaccines to prevent cholera, brain fever, whooping cough, typhoid fever, hepatitis, tetanus and many more such diseases that were once considered fatal.

Smallpox was one such disease against which mankind had no shield with which to protect himself. Like cholera, it has claimed human lives in epidemic proportions. Today, smallpox too is considered totally eradicated. The credit for the achievement goes to an English physician Edward Jenner. He was the one who developed the first effective shield, a vaccine against smallpox. His discovery, made in the year 1796 is said to have laid the foundation for the science of immunology.

 

During Jenner’s time, the protection against small pox was a procedure called variolation. We’d shudder reading about it. A substance would be obtained from the blisters on the body of a person with a mild attack of the disease. This substance would then be administered into a healthy person’s arm through scratching. The reasoning was this: A mild case could come and go away, but a person could not take chance against a severe attack. The catch here was that the procedure itself was dangerous.

How Jenner chanced upon his discovery is an interesting story. When he was working as an apprentice to a surgeon, milkmaids who came to the clinic gave him an interesting clue. They said that those who had suffered an attack of cowpox, a harmless disease generally attacking the hands and arms, usually never got small pox. At that time, Jenner was barely thirteen.
 

Edward Jenner - discoverer of the small pox vaccine
Edward Jenner

Jenner later decided to experiment and find out if cowpox was indeed a protection against the dreaded small pox. On May 14, 1796, Jenner made two small scratches on the arm of an eight-year-old boy and rubbed fluid obtained from a milkmaid’s cowpox blister. Eight days later, the boy had an attack of cowpox. There were small cowpox blisters on the scratches. About a month and a half later, Jenner administered fluid from a small pox blister through scratching, on the same boy. To Jenner’s thrill and happiness, the boy did not get even a mild attack of small pox.

With the experiment, Jenner had stumbled upon two discoveries. He had confirmed that cowpox was indeed a protection against small pox; he had also discovered that cowpox could be transmitted. He experimented on other children, including his son. He submitted his study results in the year 1798, but was unfortunately rejected. Undaunted, Jenner continued to experiment and finally published the results at his own cost.


Initially, the procedure was considered unnatural and bizarre. Decades later, Louis Pasteur showed the technique for developing modern preventive vaccines. For Jenner’s discovery, the Oxford University presented him with an honorary degree.

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